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Human Nature

A breakthrough called CRISPR opens the door to curing diseases, reshaping the biosphere, and designing our own children. A provocative exploration of its far-reaching implications, through the eyes of the scientists who discovered it

Director

Adam Bolt

Year

Genre

Box Office

$5,487

Production

Sandbox Films,News and Guts Films,The Wonder Collaborative

Awards

1 win & 4 nominations

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Jennifer Doudna

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Rodolphe Barrangou

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Antonio Regalado

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David Baltimore

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Aliza Ben-Baruch

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Emmanuelle Charpentier

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Tshaka Cunningham

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Michael Dabrowski

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Bowyer G. Freeman

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Luciano Marraffini

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Kelsey McClelland

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Francisco Mojica

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Jorge Piedrahita

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Matthew Porteus

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Dolores Sanchez

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Explore 461 Clips

Dr. Bonner,
fellow prophets, and... - Human Nature

Dr. Bonner, fellow prophets, and...

This summer,
I traveled through - Human Nature

This summer, I traveled through

In this land,
the rivers have carved - Human Nature

In this land, the rivers have carved

On that immense scale - Human Nature

On that immense scale

The dramatic advances
of the past few decades - Human Nature

The dramatic advances of the past few decades

And with this understanding - Human Nature

And with this understanding

And now the impact of science
will strike straight home, - Human Nature

And now the impact of science will strike straight home,

We will surely come to the time - Human Nature

We will surely come to the time

The prospect is, to me, - Human Nature

The prospect is, to me,

You want to squeeze my hand? - Human Nature

You want to squeeze my hand?

Relax your toes. - Human Nature

Relax your toes.

-Being in the hospital
isn't scary to me. - Human Nature

-Being in the hospital isn't scary to me.

Having a certain new problem
isn't scary to me anymore - Human Nature

Having a certain new problem isn't scary to me anymore

My blood just does not
like me very much, I guess. - Human Nature

My blood just does not like me very much, I guess.

Your red cells are
supposed to be round - Human Nature

Your red cells are supposed to be round

Mine are half-moon-shaped,
sickle-shaped, - Human Nature

Mine are half-moon-shaped, sickle-shaped,

Yeah, so he just
needs a tune-up - Human Nature

Yeah, so he just needs a tune-up

Why are you crying?" - Human Nature

Why are you crying?"

-It's often called
the first molecular disease. - Human Nature

-It's often called the first molecular disease.

It's caused by a single change
in the DNA sequence. - Human Nature

It's caused by a single change in the DNA sequence.

It's the letter A
changed to a letter T. - Human Nature

It's the letter A changed to a letter T.

-And that mutation causes
a kink in the protein - Human Nature

-And that mutation causes a kink in the protein

If your folding structure
of a protein is disrupted, - Human Nature

If your folding structure of a protein is disrupted,

It causes the red blood cell - Human Nature

It causes the red blood cell

-It becomes very stiff,
and it can't squeeze through - Human Nature

-It becomes very stiff, and it can't squeeze through

In Africa, the life expectancy - Human Nature

In Africa, the life expectancy

In the U.S.,
it's the early to mid-40s. - Human Nature

In the U.S., it's the early to mid-40s.

What do you say to a kid
that their life is gonna be-- - Human Nature

What do you say to a kid that their life is gonna be--

Makes me very nervous. - Human Nature

Makes me very nervous.

David can go from
crazy teenager, - Human Nature

David can go from crazy teenager,

"This hurts. - Human Nature

You're having
a sickle cell crisis." - Human Nature

You're having a sickle cell crisis."

This is David's
old red blood cells. - Human Nature

This is David's old red blood cells.

It's a genetic disorder, - Human Nature

It's a genetic disorder,

We just didn't have the tools - Human Nature

We just didn't have the tools

-Deoxyribonucleic acid,
or DNA for short, - Human Nature

-Deoxyribonucleic acid, or DNA for short,

Each living thing
has its unique DNA - Human Nature

Each living thing has its unique DNA

If we understood
the structure of genes, - Human Nature

If we understood the structure of genes,

The work that Paul Berg did, - Human Nature

The work that Paul Berg did,

This dream of gene therapy - Human Nature

This dream of gene therapy

The hope is that
the isolation of the gene - Human Nature

The hope is that the isolation of the gene

Scientists are
working on genetic cures - Human Nature

Scientists are working on genetic cures

A, T, A, G, C... - Human Nature

A, T, A, G, C...

-The idea behind gene therapy
is really simple: - Human Nature

-The idea behind gene therapy is really simple:

Then they'll make
the protein that works, - Human Nature

Then they'll make the protein that works,

Right now,
we have the ability - Human Nature

Right now, we have the ability

-If you put a gene
into a cell, - Human Nature

-If you put a gene into a cell,

-Conventional gene therapy - Human Nature

-Conventional gene therapy

So imagine taking this
century-long narrative, - Human Nature

So imagine taking this century-long narrative,

The change you are creating
is not a controlled one. - Human Nature

The change you are creating is not a controlled one.

The gene went into
the wrong place - Human Nature

The gene went into the wrong place

You know, you always think
that what you know - Human Nature

You know, you always think that what you know

The technology
was just too clumsy - Human Nature

The technology was just too clumsy

It became very,
very clear to us - Human Nature

It became very, very clear to us

I worked at this company
called Sangamo Biosciences. - Human Nature

I worked at this company called Sangamo Biosciences.

We decided to figure out a way - Human Nature

We decided to figure out a way

This will get technical
but good technical. - Human Nature

This will get technical but good technical.

DNA breaks all the time. - Human Nature

DNA breaks all the time.

And the X-rays
actually hit your DNA, - Human Nature

And the X-rays actually hit your DNA,

The good news is, - Human Nature

The good news is,

Inside our cells, - Human Nature

Inside our cells,

If one is broken,
it can say to its sister-- - Human Nature

If one is broken, it can say to its sister--

I'm wondering if I can copy the
missing genetic information." - Human Nature

I'm wondering if I can copy the missing genetic informa...

"Chromosome broken - Human Nature

"Chromosome broken

So it's useful because - Human Nature

So it's useful because

You fool the cell, - Human Nature

You fool the cell,

She will repair the break - Human Nature

She will repair the break

You can think of it like
a cursor in Microsoft Word. - Human Nature

You can think of it like a cursor in Microsoft Word.

In Word, if you have
a document where you edit, - Human Nature

In Word, if you have a document where you edit,

In DNA,
wherever you make a cut - Human Nature

In DNA, wherever you make a cut

So if you wanted
to use that capability - Human Nature

So if you wanted to use that capability

-How were we gonna do that? - Human Nature

-How were we gonna do that?

We need something
that cuts only one gene - Human Nature

We need something that cuts only one gene

-There were just such serious
blocks in the way. - Human Nature

-There were just such serious blocks in the way.

So it looked like
it was gonna be a long road - Human Nature

So it looked like it was gonna be a long road

David's doctor told me,
"Just hold on. - Human Nature

David's doctor told me, "Just hold on.

There's something coming." - Human Nature

There's something coming."

It was put on by a Russian guy - Human Nature

It was put on by a Russian guy

-But they had a lot
of good people there, - Human Nature

-But they had a lot of good people there,

This is going to allow
human genome engineering - Human Nature

This is going to allow human genome engineering

I mean, - Human Nature

-Well, I'll tell you
the story that I know. - Human Nature

-Well, I'll tell you the story that I know.

Microbial genome sequencing
started sometime in the 1990s. - Human Nature

Microbial genome sequencing started sometime in the 1990s.

See--okay, so unraveling the
DNA code of organisms of life. - Human Nature

See--okay, so unraveling the DNA code of organisms of life.

It's a relatively
recent part of biology, - Human Nature

It's a relatively recent part of biology,

They're amazingly
highly evolved entities - Human Nature

They're amazingly highly evolved entities

Clustered
regularly interspaced - Human Nature

Clustered regularly interspaced

-There really wasn't
much precedence - Human Nature

-There really wasn't much precedence

-CRISPR is actually clustered - Human Nature

-CRISPR is actually clustered

But what was
really interesting - Human Nature

But what was really interesting

Human Nature poster

★ ★ ★ ★ ★

A breakthrough called CRISPR opens the door to curing diseases, reshaping the biosphere, and designing our own children. A provocative exploration of its far-reaching implications, through the eyes of the scientists who discovered it

User Rating: 0.0 (0 ratings)

Director: Adam Bolt

Writer: Adam Bolt, Regina Sobel

Production: Sandbox Films,News and Guts Films,The Wonder Collaborative

Genre: documentary

Year: 2019

MetaScore: 77/100

ImdbRating: 7.7

BoxOffice: $5,487

Released: 12 Mar 2020

Awards: 1 win & 4 nominations

Homepage:

Also watch: Gully Boy, Promising Young Woman, Kingsman: The Golden Circle, Joker, Interstellar, Tenet, Snowpiercer, Avengers: Endgame, Get Out, Oppenheimer, Deadpool 2, Spider-Man: Across the Spider-Verse, Barbie, Knives Out, Extremely Wicked, Shockingly Evil and Vile, Thor: Ragnarok, Evil Dead Rise