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Human Nature

A breakthrough called CRISPR opens the door to curing diseases, reshaping the biosphere, and designing our own children. A provocative exploration of its far-reaching implications, through the eyes of the scientists who discovered it

Director

Adam Bolt

Year

Genre

Box Office

$5,487

Production

Sandbox Films,News and Guts Films,The Wonder Collaborative

Awards

1 win & 4 nominations

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Jennifer Doudna

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Rodolphe Barrangou

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Antonio Regalado

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David Baltimore

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Aliza Ben-Baruch

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Emmanuelle Charpentier

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Tshaka Cunningham

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Michael Dabrowski

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Bowyer G. Freeman

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Luciano Marraffini

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Kelsey McClelland

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Francisco Mojica

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Jorge Piedrahita

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Matthew Porteus

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Dolores Sanchez

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Explore 461 Clips

Where the hell
come these sequences from? - Human Nature

Where the hell come these sequences from?

I- have my own way of kind of - Human Nature

I- have my own way of kind of

It was CRISPR.
It was CRISPR. - Human Nature

It was CRISPR. It was CRISPR.

-The first one I got back
in the days in Wisconsin, - Human Nature

-The first one I got back in the days in Wisconsin,

One of the first things I did - Human Nature

One of the first things I did

People were like, - Human Nature

People were like,

-Danisco is a company
that sells microbes - Human Nature

-Danisco is a company that sells microbes

A lot of foods are produced
using bacteria, and-- - Human Nature

A lot of foods are produced using bacteria, and--

Rodolphe was trying
to work out how to deal - Human Nature

Rodolphe was trying to work out how to deal

Most people don't wake up
in the morning and think about - Human Nature

Most people don't wake up in the morning and think abou...

Sort of front and center
in people's agenda, - Human Nature

Sort of front and center in people's agenda,

-Viruses are very simple
lean machines. - Human Nature

-Viruses are very simple lean machines.

They have one job to do: - Human Nature

They have one job to do:

That's it. - Human Nature

-The virus will
attach to the surface, - Human Nature

-The virus will attach to the surface,

It hijacks the cell
and use the cell - Human Nature

It hijacks the cell and use the cell

And then it's over. - Human Nature

And then it's over.

This is when people - Human Nature

This is when people

But there's a small subset
of the population - Human Nature

But there's a small subset of the population

At that time, - Human Nature

Then what we do is, we take
the survivor that made it, - Human Nature

Then what we do is, we take the survivor that made it,

-And now it's immune. - Human Nature

-And now it's immune.

-So now
scientists have a clue, - Human Nature

-So now scientists have a clue,

You lose the resistance. - Human Nature

You lose the resistance.

Without that
little piece of DNA, - Human Nature

Without that little piece of DNA,

Oh, that was like--
that was like, - Human Nature

Oh, that was like-- that was like,

What an idea, a piece of
the genome of your predator - Human Nature

What an idea, a piece of the genome of your predator

-At the time, you know, - Human Nature

-At the time, you know,

We have no idea how useful
another's technology - Human Nature

We have no idea how useful another's technology

-I think I first
heard about it - Human Nature

-I think I first heard about it

One thing they'll write
on my tombstone is, - Human Nature

One thing they'll write on my tombstone is,

-I love things that
not a lot of people - Human Nature

-I love things that not a lot of people

Not anymore, but--
but, you know, - Human Nature

Not anymore, but-- but, you know,

But then you always
ask yourself, - Human Nature

But then you always ask yourself,

-We're biochemists
in the lab. - Human Nature

-We're biochemists in the lab.

We study the way
molecules work. - Human Nature

We study the way molecules work.

We try to isolate them from - Human Nature

We try to isolate them from

We love to ask, - Human Nature

We love to ask,

-When an invader shows up, - Human Nature

-When an invader shows up,

When the invader comes back, - Human Nature

When the invader comes back,

When Cas9 polices the
intercellular neighborhood - Human Nature

When Cas9 polices the intercellular neighborhood

Do you contain an exact match - Human Nature

Do you contain an exact match

-The thing about Cas9
that struck me at the time - Human Nature

-The thing about Cas9 that struck me at the time

As a tool, right,
you could immediately see - Human Nature

As a tool, right, you could immediately see

I will never forget - Human Nature

I will never forget

Cas9 cuts DNA based on an
instruction that it carries, - Human Nature

Cas9 cuts DNA based on an instruction that it carries,

-RNA, I think about it
as DNA's chemical cousin. - Human Nature

-RNA, I think about it as DNA's chemical cousin.

Like DNA, it has four letters, - Human Nature

Like DNA, it has four letters,

The letters in the RNA
allow Cas9 - Human Nature

The letters in the RNA allow Cas9

Bacteria were programming
this thing all the time - Human Nature

Bacteria were programming this thing all the time

But because it's using
these little RNA molecules, - Human Nature

But because it's using these little RNA molecules,

RNA molecules
are trivial to make - Human Nature

RNA molecules are trivial to make

And I can cut any DNA I want
just by changing this-- - Human Nature

And I can cut any DNA I want just by changing this--

It was clearly a useful tool, - Human Nature

It was clearly a useful tool,

I was thinking about
all the cool experiments - Human Nature

I was thinking about all the cool experiments

I wasn't thinking about, - Human Nature

I wasn't thinking about,

In my left hand here,
I have purified Cas9 nuclease, - Human Nature

In my left hand here, I have purified Cas9 nuclease,

It's actually millions
of Cas9 molecules, - Human Nature

It's actually millions of Cas9 molecules,

I have to say it didn't
immediately hit me - Human Nature

I have to say it didn't immediately hit me

You know, it was real. - Human Nature

You know, it was real.

You can actually use CRISPR
in humans to change DNA. - Human Nature

You can actually use CRISPR in humans to change DNA.

Here's a copy
of a human gene. - Human Nature

Here's a copy of a human gene.

You give it to Cas9 and
put it inside human cells. - Human Nature

You give it to Cas9 and put it inside human cells.

It runs away, finds that DNA,
and cuts it. - Human Nature

It runs away, finds that DNA, and cuts it.

-Before CRISPR, we were
getting 1% to 2% correction. - Human Nature

-Before CRISPR, we were getting 1% to 2% correction.

This could really
cure a patient. - Human Nature

This could really cure a patient.

-I think it's gonna help
a lot of people, - Human Nature

-I think it's gonna help a lot of people,

And I know so many
other people - Human Nature

And I know so many other people

He...uh, had leukemia. - Human Nature

He...uh, had leukemia.

He actually--he didn't make it
out of the hospital. - Human Nature

He actually--he didn't make it out of the hospital.

If he had it
just a little bit later, - Human Nature

If he had it just a little bit later,

-CRISPR has,
really, the ability - Human Nature

-CRISPR has, really, the ability

It's really a universal tool. - Human Nature

It's really a universal tool.

-We have
thousands of customers - Human Nature

-We have thousands of customers

Specify a gene that
you're looking to knock out. - Human Nature

Specify a gene that you're looking to knock out.

You can specify
the types of edit - Human Nature

You can specify the types of edit

You swipe your credit card,
and a few days later, - Human Nature

You swipe your credit card, and a few days later,

Obviously we like to validate
the researchers' authenticity - Human Nature

Obviously we like to validate the researchers' authenti...

There were cars
before there were Model Ts, - Human Nature

There were cars before there were Model Ts,

Ford comes out with
the Model T, and, suddenly, - Human Nature

Ford comes out with the Model T, and, suddenly,

-CRISPR gives us the chance
to make precise, - Human Nature

-CRISPR gives us the chance to make precise,

Can you just sort of describe
where we are right now? - Human Nature

Can you just sort of describe where we are right now?

-The field is called
xenotransplantation, - Human Nature

-The field is called xenotransplantation,

These things have
actually been tried a lot, - Human Nature

These things have actually been tried a lot,

So it's a--you know,
conceptually, - Human Nature

So it's a--you know, conceptually,

Whether we like
to believe or not, - Human Nature

Whether we like to believe or not,

This pig, this pig, this pig, - Human Nature

This pig, this pig, this pig,

Novartis had had a
billion-dollar investment in it - Human Nature

Novartis had had a billion-dollar investment in it

They did--they just didn't
have the technology. - Human Nature

They did--they just didn't have the technology.

-Luhan Yang and her team, - Human Nature

-Luhan Yang and her team,

Human Nature poster

★ ★ ★ ★ ★

A breakthrough called CRISPR opens the door to curing diseases, reshaping the biosphere, and designing our own children. A provocative exploration of its far-reaching implications, through the eyes of the scientists who discovered it

User Rating: 0.0 (0 ratings)

Director: Adam Bolt

Writer: Adam Bolt, Regina Sobel

Production: Sandbox Films,News and Guts Films,The Wonder Collaborative

Genre: documentary

Year: 2019

MetaScore: 77/100

ImdbRating: 7.7

BoxOffice: $5,487

Released: 12 Mar 2020

Awards: 1 win & 4 nominations

Homepage:

Also watch: Gully Boy, Promising Young Woman, Kingsman: The Golden Circle, Joker, Interstellar, Tenet, Snowpiercer, Avengers: Endgame, Get Out, Oppenheimer, Deadpool 2, Spider-Man: Across the Spider-Verse, Barbie, Knives Out, Extremely Wicked, Shockingly Evil and Vile, Thor: Ragnarok, Evil Dead Rise