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Cas9 cuts DNA based on an instruction that it carries
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Human Nature

Cas9 cuts DNA based on aninstruction that it carries, and that instructionis a molecule of...

Cas9 cuts DNA based on an
instruction that it carries, and that instruction
is a molecule of RNA that matches perfectly
the DNA of the invader

Full Transcript

00:00:01.000 --> 00:00:04.568
Cas9 cuts DNA based on an instruction that it carries,
00:00:04.612 --> 00:00:08.572
and that instruction is a molecule of RNA
00:00:08.616 --> 00:00:13.273
that matches perfectly the DNA of the invader.
Duration
13 seconds
Views
16
Timestamp in Movie
00:29:33
Uploaded
Jun 10, 2025
Genres
documentary
Production
Sandbox Films,News and Guts Films,The Wonder Collaborative

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Movie Summary

A breakthrough called CRISPR opens the door to curing diseases, reshaping the biosphere, and designing our own children. A provocative exploration of its far-reaching implications, through the eyes of the scientists who discovered it
-RNA, I think about it as DNA's chemical cousin. - Human Nature 00:05
-RNA, I think about it as DNA's chemical cousin.
Like DNA, it has four letters, - Human Nature 00:11
Like DNA, it has four letters,
The letters in the RNA allow Cas9 - Human Nature 00:08
The letters in the RNA allow Cas9
Bacteria were programming this thing all the time - Human Nature 00:09
Bacteria were programming this thing all the time
But because it's using these little RNA molecules, - Human Nature 00:08
But because it's using these little RNA molecules,
RNA molecules are trivial to make - Human Nature 00:07
RNA molecules are trivial to make
And I can cut any DNA I want just by changing this-- - Human Nature 00:06
And I can cut any DNA I want just by changing this--
It was clearly a useful tool, - Human Nature 00:06
It was clearly a useful tool,
I was thinking about all the cool experiments - Human Nature 00:05
I was thinking about all the cool experiments
I wasn't thinking about, - Human Nature 00:12
I wasn't thinking about,
In my left hand here, I have purified Cas9 nuclease, - Human Nature 00:14
In my left hand here, I have purified Cas9 nuclease,
It's actually millions of Cas9 molecules, - Human Nature 00:08
It's actually millions of Cas9 molecules,
I have to say it didn't immediately hit me - Human Nature 00:11
I have to say it didn't immediately hit me
You know, it was real. - Human Nature 00:05
You know, it was real.
You can actually use CRISPR in humans to change DNA. - Human Nature 00:05
You can actually use CRISPR in humans to change DNA.
Here's a copy of a human gene. - Human Nature 00:05
Here's a copy of a human gene.
You give it to Cas9 and put it inside human cells. - Human Nature 00:06
You give it to Cas9 and put it inside human cells.
It runs away, finds that DNA, and cuts it. - Human Nature 00:04
It runs away, finds that DNA, and cuts it.
-Before CRISPR, we were getting 1% to 2% correction. - Human Nature 00:05
-Before CRISPR, we were getting 1% to 2% correction.
This could really cure a patient. - Human Nature 00:07
This could really cure a patient.