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The thing about Cas9 that struck me at the time
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Human Nature

The thing about Cas9that struck me at the time was that, you know,fundamentally, this...

The thing about Cas9
that struck me at the time was that, you know,
fundamentally, this thing was
a programmable protein that finds and cuts DNA

Full Transcript

00:00:01.000 --> 00:00:03.306
-The thing about Cas9 that struck me at the time
00:00:03.035 --> 00:00:05.482
was that, you know, fundamentally,
00:00:05.526 --> 00:00:09.001
this thing was a programmable protein
00:00:09.138 --> 00:00:13.142
that finds and cuts DNA.
Duration
13 seconds
Views
18
Timestamp in Movie
00:28:44
Uploaded
Jun 11, 2025
Genres
documentary
Production
Sandbox Films,News and Guts Films,The Wonder Collaborative

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Movie Summary

A breakthrough called CRISPR opens the door to curing diseases, reshaping the biosphere, and designing our own children. A provocative exploration of its far-reaching implications, through the eyes of the scientists who discovered it
As a tool, right, you could immediately see - Human Nature 00:07
As a tool, right, you could immediately see
I will never forget - Human Nature 00:20
I will never forget
Cas9 cuts DNA based on an instruction that it carries, - Human Nature 00:13
Cas9 cuts DNA based on an instruction that it carries,
-RNA, I think about it as DNA's chemical cousin. - Human Nature 00:05
-RNA, I think about it as DNA's chemical cousin.
Like DNA, it has four letters, - Human Nature 00:11
Like DNA, it has four letters,
The letters in the RNA allow Cas9 - Human Nature 00:08
The letters in the RNA allow Cas9
Bacteria were programming this thing all the time - Human Nature 00:09
Bacteria were programming this thing all the time
But because it's using these little RNA molecules, - Human Nature 00:08
But because it's using these little RNA molecules,
RNA molecules are trivial to make - Human Nature 00:07
RNA molecules are trivial to make
And I can cut any DNA I want just by changing this-- - Human Nature 00:06
And I can cut any DNA I want just by changing this--
It was clearly a useful tool, - Human Nature 00:06
It was clearly a useful tool,
I was thinking about all the cool experiments - Human Nature 00:05
I was thinking about all the cool experiments
I wasn't thinking about, - Human Nature 00:12
I wasn't thinking about,
In my left hand here, I have purified Cas9 nuclease, - Human Nature 00:14
In my left hand here, I have purified Cas9 nuclease,
It's actually millions of Cas9 molecules, - Human Nature 00:08
It's actually millions of Cas9 molecules,
I have to say it didn't immediately hit me - Human Nature 00:11
I have to say it didn't immediately hit me
You know, it was real. - Human Nature 00:05
You know, it was real.
You can actually use CRISPR in humans to change DNA. - Human Nature 00:05
You can actually use CRISPR in humans to change DNA.
Here's a copy of a human gene. - Human Nature 00:05
Here's a copy of a human gene.
You give it to Cas9 and put it inside human cells. - Human Nature 00:06
You give it to Cas9 and put it inside human cells.